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Ceftolozane/Tazobactam Intravenous Infusion for Adults
Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
- Zerbaxa vial contains ceftolozane 1g and tazobactam 0.5g. Prescribe as combination i.e. 1g/0.5g, 2g/1g etc
- Restricted to Microbiology or Infectious Diseases advice only (Red-light antimicrobial)
- If documented IMMEDIATE, or SEVERE DELAYED hypersensitivity REACTION to PENICILLIN, CEPHALOSPORINS or CARBAPENEMS: DO NOT GIVE THIS DRUG
- Contains Sodium (10mmol per vial)
- See under Dose for adjustments required in Renal impairment
Available preparations
Zerbaxa vial (ceftolozane 1g and tazobactam 0.5g)
Reconstitution
Water for injection or Sodium chloride 0.9%
- 10ml per 1.5g vial
- Shake gently to dissolve the powder
- Final volume 11.4ml per vial
- Dilute further prior to administration
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion
- Any dose may be added to 100ml infusion fluid and administer over 60 minutes
| Dose of Ceftolazone/tazobactam | Volume of reconstituted injection |
|---|---|
| 2g/1g | 22.8ml (two vials) |
| 1.5g/0.75g | 17.1ml |
| 1g/0.5g | 11.4ml (one vial) |
| 500mg/250mg | 5.7ml |
| 300mg/150mg | 3.5ml |
| 250mg/125mg | 2.9ml |
| 100mg/50mg | 1.2ml |
Dose in adults
Complicated intra-abdominal infection, Complicated urinary tract infection, Acute Pyelonephritis
- Give 1g ceftolazone / 0.5g tazobactam (one vial) every eight hours
Hospital acquired pneumonia, including ventilator-associated pneumonia
- Give 2g ceftolazone /1g tazobactam (two vials) every eight hours
| Renal impairment (ref 1) | ||
|---|---|---|
| See table in Methods of administration for how to work out doses below- eg 500mg/250mg- use 5.7ml reconstituted solution | ||
| Estimated CrCl (ml/min) | Complicated intra-abdominal infection, Complicated urinary tract infection, Acute Pyelonephritis | Hospital acquired pneumonia, including ventilator-associated pneumonia |
| 30 to 50 | give 500mg cetolazone / 250mg tazobactam every 8 hours | give 1g ceftolazone /0.5g tazobactam every 8 hours |
| 15 to 29 | give 250mg ceftolazone / 125mg tazobactam every 8 hours | give 500mg ceftolazone /250mg tazobactam every 8 hours |
| End stage renal disease or Haemodialysis | give a single loading dose of 500mg cetolazone /250mg tazobactam, followed 8 hours later by maintenance dose of 100mg ceftolazone /50mg tazobactam every 8 hours. Administer dose immediately after dialysis on dialysis days | give a single loading dose of 1.5g ceftolazone /0.75g tazobactam, followed 8 hours later by maintenance dose of 300mg ceftolazone / 150mg tazobactam every 8 hours. Administer dose immediately after dialysis on dialysis days |
Hepatic impairment
- No dosage adjustment required
Storage
- Store between 2 and 80C
References
- SPC 17th April 2020
1: eGFR used instead of CrCl- as approved by AST. Email on file from Dr Una NiRiain 10/01/2017
Therapeutic classification
Cephalosporin antibiotic (fifth generation) with beta-lacatamase inhibitor