Bumetanide intravenous injection for adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Important information

• Unlicensed preparation

Available preparations

Burinex 2mg per 4ml ampoule (Swedish preparation)

Reconstitution

Not required- already in solution

Infusion fluids

Sodium chloride 0.9% or Glucose 5% ^{(ref 1)}

Methods of intravenous administration

Slow intravenous injection ^{(ref 2)}

• Doses up to 2mg only
• Administer slowly over 1 to 2 minutes

Intermittent intravenous infusion

• For doses over 2mg
• Add required dose to a suitable volume of infusion fluid
• While 500mL has been suggested as a suitable volume, solutions containing 1mg per 10mL have been used. If a 50mL infusion volume is used the residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
• Administer over 30 to 60 minutes
• Protect from direct sunlight ^{(ref 2)}

Dose in adults

Slow intravenous injection or intermittent intravenous infusion ^{(ref 1)}

• Give 0.5 to 1mg per dose
• If diuretic response to initial dose is not adequate, may repeat in two to three hours for up to 2 doses
• Maximum dose is 10mg/day

Elderly patients ^{(ref 2)}

• Use lower doses

Monitoring

• Monitor fluid balance and electrolytes closely
• Monitor blood glucose levels
• Monitor blood pressure
• Monitor LFTs and renal function ^{(ref 2)}

Storage

Store below 25⁰C

References

SPC Burinex, 23rd May 2017

1. Uptodate, downloaded 9th May 2023

2. Injectable drugs guide, downloaded 9th May 2023

Therapeutic classification

Loop diuretic