May be administered by registered competent doctor or nurse/midwife
Fomicyt 4g vial
Glucose 5% ONLY (see further information below)
Intermittent intravenous infusion
Usual dose (ref 1,3)
Indication | Daily dose |
---|---|
Cystic fibrosis (unlicensed)(ref 2) | 4g every six hours |
Complicated urinary tract infection | 8g every twelve hours |
Nosocomial lower respiratory tract infection | 8g every eight hours |
CPE infection (adults) in combination with other antimicrobials | See page 39 of National Guidelines |
Maximum 8g per dose
Elderly patient: Use usual recommended dose. Reduce dose if evidence of renal impairment
Renal impairment FOR CYSTIC FIBROSIS (ref 2) | |
---|---|
Use with GREAT CAUTION in patients with renal impairment. Discuss with Micro/ID/CF consultant before using in any patient with renal impairment. | |
eGFR (ml/min/1.73m2) | Recommended dose |
30 to 40 | 8g loading dose, then 4g every eight hours |
20 to 30 | 6g loading dose, then 3g every eight hours |
10 to 20 | 4g loading dose, then 2g every eight hours |
less than 10 | 2g loading dose, then 1g every eight hours |
Intermittent haemodialysis | 2g loading dose, then 2g at the end of each dialysis session |
Renal impairment for indications NOT cystic fibrosis (ref 1,3) | ||
---|---|---|
Use with GREAT CAUTION in patients with renal impairment. Discuss with Micro/ID consultant before using in any patient with renal impairment. | ||
eGFR (ml/min/1.73m2) | UTI | Other infections |
30 to 40 | 8g loading dose, then 6g bd | 8g loading dose, then 8g bd |
20 to 30 | 8g loading dose, then 4g bd | 8g loading dose, then 6g bd |
10 to 20 | 6g loading dose, then 3g bd | 8g loading dose, then 4g bd |
less than 10 | 6g loading dose, then 3g od | 8g loading dose, then 4g od |
Intermittent haemodialysis | 2g loading dose, and then 2g at the end of each dialysis session | |
Continuous renal replacement therapy (RRT) | Post-dilution CVVHF - give usual dose. Pre-dilution CVVHF or other forms of RRT: no clinical data |
Hepatic impairment: No dosage adjustment necessary
Store below 250C
1:Fomicyt SPC Oct 2021
2: Nottingham University Hospitals: Adult Cystic Fibrosis Intravenous Antibiotic Dosing and Administration Guideline May 2020, together with email correspondence 4th Nov 2021
3: Dosage schedules simplified, as agreed with Dr Una Ni Riain, Microbiologist 26/3/2015
Antibiotic