Who can administer
May be administered by registered competent doctor or nurse/midwife
Available preparations
Granisetron 1mg per 1ml ampoule
Kytril 1mg per 1ml ampoule
Reconstitution
Already in solution
Dilute further prior to administration
Draw up using a 5 micron filter needle
Infusion fluids
Sodium Chloride 0.9%
Glucose 5%
Methods of intravenous administration
Can use either method of administration- choice depends on practicalities such as time available, fluid status of patient, etc.
Bolus intravenous injection
- Dilute 1mg to 5ml with infusion fluid and give over at least 30 seconds
- Dilute 3mg to 15ml with infusion fluid and give over at least 30 seconds
Intermittent intravenous infusion:
- Dilute required dose in 20 to 50ml of infusion fluid and administer over five minutes
- The residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
Dose in adults
Post operative nausea and vomiting
- Give 1mg stat, with a maximum of 3 doses (3mg) in 24 hours
Nausea associated with cytostatic therapy (Prevention)
- Give 1 to 3mg, five minutes prior to the start of chemotherapy
Nausea associated with cytostatic therapy (Treatment)
- Give 1 to 3mg generally, additional doses should be administered at least 10 minutes apart.
- Maximum of 9mg in 24 hours
Monitoring
- Monitor QTc, especially in patients with cardiac co-mobidities, on cardiotoxic chemotherapy and/or with electrolyte abnormalities
Storage
- Store below 250C
- Do not freeze
References
Kytril SPC March 2021
Therapeutic classification
Drugs used in nausea and vomiting
Kytril (search term)
