Metronidazole Intravenous for Adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Important information

  • Cefuroxime doses of either 750mg or 1.5g may be added to the metronidazole bag (ref 1)
  • Remind patient that alcohol must be avoided during therapy, and for 48 hours afterwards, because of the possibility of a disulfiram-like reaction.
  • For Y-site compatibility see below

Available preparations

Flagyl 500mg per 100ml infusion bag

Reconstitution

Already in solution

Infusion fluids

Not required - product ready for infusion

Methods of intravenous administration

Intermittent intravenous infusion

  • Usually administered over 20 minutes (range 20 to 60 minutes)

Dose in adults

Usual dose

  • Give 500mg every eight hours

Severe liver disease

  • Consider dose reduction in severe impairment (risk of decreased clearance)

Storage

Store below 250C

References

SPC July 2018

1. Injectable medicines guide- downloaded from Medusa 3/11/2021

2. BNF- downloaded 18/11/2021

Therapeutic classification

Antimicrobial