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Dexmedetomidine INTRAVENOUS for Adults
Who can administer
Administration RESTRICTED - see Appendix 1
Important information
- May only be initiated by a Consultant Intensivist/Anaesthetist.
- Doses in excess of the licensed maximum of 1.4microgram/kg/hour must also be authorised by consultant.
- AVOID a loading dose in ICU sedation (increased adverse reactions)
- There is no experience with use of this drug for longer than 14 days
- Cardiovascular contraindications include: advanced heart block (grade 2 or 3) unless paced, uncontrolled hypotension, acute cerebrovascular conditions
- An unlicensed concentration of 10microgram/ml is being used on the intensive care unit for safety and pharmacoeconomic reasons (ref 1)
- For Y-site compatibility see below
Available preparations
Dexdor solution for infusion 400microgram in 4ml (for use in Critical Care only)
Dexdor solution for infusion 200microgram in 2ml (for use in Theatres only)
Reconstitution
Already in solution
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
For Intensive Care use (longer term)
- Add 4ml (400 micrograms) to 36ml of diluent (final concentration of 10micrograms/ml) (ref 1)
For Theatres
- Add 2ml (200 micrograms) to 48ml of diluent (final concentration of 4micrograms/ml)
Concentrations above 4microgram/ml: administer via a large vein or preferably through a dedicated port of a central line (ref 1)
Dose in adults
A: Starting dose for use in intensive care as per license
A1. Intensive Care
- 0.7microgram/kg/hour - but frail patients may require lower starting doses
A2. Maintenance dose for use in intensive care as per license
- Normally 0.2 to 1.4microgram/kg/hour
- Exceptionally unlicensed doses up to 2.5microgram/kg/hour - at consultants discretion (ref 2)
- After dose adjustment, a new steady state sedation level may not be reached for up to one hour
ICU USE ONLY: Dexmedetomidine 10microgram/ml: flow rates in ml/hour | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose (micrograms/kg/hour) | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9 | 1 | 1.1 | 1.2 | 1.3 | 1.4 |
Weight (kg) | |||||||||||||
35kg, using 400mcg/40ml | 0.7 | 1.1 | 1.4 | 1.8 | 2.1 | 2.5 | 2.8 | 3.2 | 3.5 | 3.9 | 4.2 | 4.6 | 4.9 |
40kg, using 400mcg/40ml | 0.8 | 1.2 | 1.6 | 2 | 2.4 | 2.8 | 3.2 | 3.6 | 4 | 4.4 | 4.8 | 5.2 | 5.6 |
45kg, using 400mcg/40ml | 0.9 | 1.4 | 1.8 | 2.3 | 2.7 | 3.2 | 3.6 | 4.1 | 4.5 | 5 | 5.4 | 5.9 | 6.3 |
50kg, using 400mcg/40ml | 1 | 1.5 | 2 | 2.5 | 3 | 3.5 | 4 | 4.5 | 5 | 5.5 | 6 | 6.5 | 7 |
55kg, using 400mcg/40ml | 1.1 | 1.7 | 2.2 | 2.8 | 3.3 | 3.9 | 4.4 | 5 | 5.5 | 6.1 | 6.6 | 7.2 | 7.7 |
60kg, using 400mcg/40ml | 1.2 | 1.8 | 2.4 | 3 | 3.6 | 4.2 | 4.8 | 5.4 | 6 | 6.6 | 7.2 | 7.8 | 8.4 |
65kg, using 400mcg/40ml | 1.3 | 2 | 2.6 | 3.3 | 3.9 | 4.6 | 5.2 | 5.9 | 6.5 | 7.2 | 7.8 | 8.5 | 9.1 |
70kg, using 400mcg/40ml | 1.4 | 2.1 | 2.8 | 3.5 | 4.2 | 4.9 | 5.6 | 6.3 | 7 | 7.7 | 8.4 | 9.1 | 9.8 |
75kg, using 400mcg/40ml | 1.5 | 2.3 | 3 | 3.8 | 4.5 | 5.3 | 6 | 6.8 | 7.5 | 8.3 | 9 | 9.8 | 10.5 |
80kg, using 400mcg/40ml | 1.6 | 2.4 | 3.2 | 4 | 4.8 | 5.6 | 6.4 | 7.2 | 8 | 8.8 | 9.6 | 10.4 | 11.2 |
85kg, using 400mcg/40ml | 1.7 | 2.6 | 3.4 | 4.3 | 5.1 | 6 | 6.8 | 7.7 | 8.5 | 9.4 | 10.2 | 11.1 | 11.9 |
90kg, using 400mcg/40ml | 1.8 | 2.7 | 3.6 | 4.5 | 5.4 | 6.3 | 7.2 | 8.1 | 9 | 9.9 | 10.8 | 11.7 | 12.6 |
95kg, using 400mcg/40ml | 1.9 | 2.9 | 3.8 | 4.8 | 5.7 | 6.7 | 7.6 | 8.6 | 9.5 | 10.5 | 11.4 | 12.4 | 13.3 |
100kg, using 400mcg/40ml | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
105kg, using 400mcg/40ml | 2.1 | 3.2 | 4.2 | 5.3 | 6.3 | 7.4 | 8.4 | 9.5 | 10.5 | 11.6 | 12.6 | 13.7 | 14.7 |
110kg, using 400mcg/40ml | 2.2 | 3.3 | 4.4 | 5.5 | 6.6 | 7.7 | 8.8 | 9.9 | 11 | 12.1 | 13.2 | 14.3 | 15.4 |
115kg, using 400mcg/40ml | 2.3 | 3.5 | 4.6 | 5.8 | 6.9 | 8.1 | 9.2 | 10.4 | 11.5 | 12.7 | 13.8 | 15 | 16.1 |
120kg, using 400mcg/40ml | 2.4 | 3.6 | 4.8 | 6 | 7.2 | 8.4 | 9.6 | 10.8 | 12 | 13.2 | 14.4 | 15.6 | 16.8 |
125kg, using 400mcg/40ml | 2.5 | 3.8 | 5 | 6.3 | 7.5 | 8.8 | 10 | 11.3 | 12.5 | 13.8 | 15 | 16.3 | 17.5 |
130kg, using 400mcg/40ml | 2.6 | 3.9 | 5.2 | 6.5 | 7.8 | 9.1 | 10.4 | 11.7 | 13 | 14.3 | 15.6 | 16.9 | 18.2 |
135kg, using 400mcg/40ml | 2.7 | 4.1 | 5.4 | 6.8 | 8.1 | 9.5 | 10.8 | 12.2 | 13.5 | 14.9 | 16.2 | 17.6 | 18.9 |
140kg, using 400mcg/40ml | 2.8 | 4.2 | 5.6 | 7 | 8.4 | 9.8 | 11.2 | 12.6 | 14 | 15.4 | 16.8 | 18.2 | 19.6 |
145kg, using 400mcg/40ml | 2.9 | 4.4 | 5.8 | 7.3 | 8.7 | 10.2 | 11.6 | 13.1 | 14.5 | 16 | 17.4 | 18.9 | 20.3 |
150kg, using 400mcg/40ml | 3 | 4.5 | 6 | 7.5 | 9 | 10.5 | 12 | 13.5 | 15 | 16.5 | 18 | 19.5 | 21 |
155kg, using 400mcg/40ml | 3.1 | 4.7 | 6.2 | 7.8 | 9.3 | 10.9 | 12.4 | 14 | 15.5 | 17.1 | 18.6 | 20.2 | 21.7 |
B. Theatres
B1. For the initiation of Procedural/awake Sedation
- Give a loading infusion of 1microgram/kg over 10 minutes
- For less invasive procedures e.g. ophthalmic surgery give 0.5 micrograms/kg over 10 minutes
B2. For the maintenance of Procedural Sedation
- The maintenance infusion is usually started at 0.6-0.7 microgram/kg/hour.
- Titrate to desired clinical effect with doses ranging from 0.2 to 1 microgram/kg/hour.
- Adjust the rate of the maintenance infusion to achieve the targeted level of sedation
THEATRES USE ONLY : Dexmedetomidine 200microgram in 50ml | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Weight (kg) | 30kg | 40kg | 50kg | 60kg | 70kg | 80kg | 90kg | 100kg | 110kg | 120kg | 130kg | 140kg | 150kg | 160kg |
LOADING dose in microgram (mcg) (give 50% for light sedation) | 30mcg | 40mcg | 50mcg | 60mcg | 70mcg | 80mcg | 90mcg | 100mcg | 110mcg | 120mcg | 130mcg | 140mcg | 150mcg | 160mcg |
INITIAL MAINTENANCE DOSE(ml/hour)(@0.65mcg/kg/hr) using 200microgram/50ml saline or glucose 5% |
4.9ml/hr | 6.5ml/hr | 8.1ml/hr | 9.8ml/hr | 11.4ml/hr | 13ml/hr | 14.6ml/hr | 16.3ml/hr | 17.9ml/hr | 19.5ml/hr | 21.1ml/hr | 22.8ml/hr | 24.4ml/hr | 26ml/hr |
LOW END OF THERAPEUTIC RANGE(ml/hour) @0.2mcg/kg/using 200microgram/50ml saline or glucose 5% | 1.5ml/hr | 2ml/hr | 2.5ml/hr | 3ml/hr | 3.5ml/hr | 4ml/hr | 4.5ml/hr | 5ml/hr | 5.5ml/hr | 6ml/hr | 6.5ml/hr | 7ml/hr | 7.5ml/hr | 8ml/hr |
HIGH END OF THERAPEUTIC RANGE (ml/hour) @1mcg/kg/using 200microgram/50ml saline or glucose 5% | 7.5ml/hr | 10ml/hr | 12.5ml/hr | 15ml/hr | 17.5ml/hr | 20ml/hr | 22.5ml/hr | 25ml/hr | 27.5ml/hr | 30ml/hr | 32.5ml/hr | 35ml/hr | 37.5ml/hr | 40ml/hr |
Hepatic impairment
- Use with caution. Lower doses may be required
Monitoring
- Monitor for additive effects where midazolam or propofol are concerned. Midazolam or propofol may be administered if needed until clinical effects of dexmedetomidine are established
- Monitor for cardiovascular side effects such as: bradycardia, hypotension and hypertension (ref 3), especially if using other agents with this side effect profile e.g. beta-blockers
- Monitor for respiratory depression, airway obstruction, dypsnoea and oxygen desaturation when administered for conscious sedation
- If concentrations above 4microgram/ml are being used, monitor the area distal to the infusion for evidence of irritation (ref 1)
Storage
Store below 250C
References
SPC Dexdor SP 13/01/2020
- "Infusion concentration information". Email received from Orion Pharma via Anne Heavey on 20 March 2013. Email received from Julie Boothe 19 November 2018
- Written communication from Dr Patrick Neligan Jan 21 2015 and November 7 2018
- Uptodate - accessed online 16/11/2021
Therapeutic classification
Selective alpha-2 receptor agonist
BNF
IV Guide Type