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Dalbavancin intravenous infusion for Adults
Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
- Red light antimicrobial- requires Micro/ID pre-approval
- Not routinely kept in stock- ordered on the instruction of Micro/ID only (ref 1)
- See under Dose for adjustments required in Renal impairment
- Caution if known hypersensitivity to other glycopeptides as cross-sensitivity may occur
- Note: rapid administration can cause reactions including flushing of the upper body, urticaria, pruritis and/or rash. Stopping or slowing the infusion may result in cessation of these reactions
Available preparations
Xydalba 500mg vial (Europe)
Reconstitution
Water for injection
25mL per 500mg vial
- Do NOT shake. To avoid foaming alternate between gently swirling and inverting the vial until the powder is dissolved
- Reconstitution time may be up to 5 minutes
- Dilute further prior to administration
Infusion fluids
Glucose 5% ONLY
If giving other drugs via the same line, the line must be flushed before and after each dalbavancin infusion with Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion
- Add required dose to a suitable volume of infusion fluid to give a final concentration of 1mg/mL to 5mg/mL and administer over 30 minutes
Required Dose | Volume of reconstituted solution | Suggested volume of infusion fluid bag |
---|---|---|
1.5g (1500mg) | 75mL | add 75mL to 250mL bag* see below |
1g (1000mg) | 50mL | 250mL |
750mg | 37.5mL | 250mL |
500mg | 25mL | 100mL or 250mL |
375mg | 18.75mL | 100mL or 250mL |
* a 1.5g dose may be added to any volume between 225mL and 1425mL (to give a concentration of 1 to 5mg/mL) so addition to a 250mL bag has been suggested |
Dose in adults
Usual dose
Skin and soft tissue infection (licensed indication)
- Give 1.5g (1500mg) as a single dose OR
- Give 1g (1000mg) followed one week later by 500mg
Other infections:
- Alternative dosing regimens may be used if recommended for off-label use in other types of infection by a Microbiology or Infectious Diseases consultant
Renal impairment
- CrCl less than 30 ml/minute (not on regular haemodialysis)
- Give 1g (1000mg) as a single dose OR
- Give 750mg followed one week later by 375mg
- On regular intermittent haemodialysis (three times per week):
- Dose adjustment not required
Hepatic impairment
- Caution in moderate or severe hepatic impairment (Child-Pugh B & C)- no data available to guide dosing
Storage
- Store below 250C
References
SPC Xydalba 10/2020
1: Email on file from Antimicrobial Stewardship team, 21st Feb 2019
2: Email on file- now a red light antimicrobial- June 2022
Therapeutic classification
Lipoglycopeptide
IV Guide Type