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Cyclizine Intravenous for Adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Available preparations

Valoid 50mg per 1ml ampoule

Reconstitution

Already in solution

Draw up using a 5 micron filter needle

Infusion fluids

Not applicable - product ready for use

Methods of intravenous administration

Slow intravenous injection

  • Administer over at least 3 minutes (ref 1)  as rapid intravenous injection can lead to symptoms similar to those of overdose
  • If the volume is too small to be given as a slow intravenous injection, it may be diluted with 5 to 10ml Water for injections, Sodium chloride 0.9% or Glucose 5%.  Immediately after dilution, and again just before administration, check the solution for signs of precipitation.  Discard if there is any cloudiness or haze formation (unlicensed) (ref 1)

Dose in adults

Usual dose

  • Nausea and vomiting: 50mg, repeated up to three times daily
  • Prevention of post-operative nausea: Give 50mg, 20 minutes before anticipated end of surgery
  • Prevention of regurgitation and aspiration during emergency surgery: Give 25mg before induction of general anaesthesia

Further information

  • Case reports of paralysis in patients using intravenous cyclizine - use with particular caution in patients with underlying neuromuscular disorders 
  • Cyclizine can have a hypotensive effect when given by the intravenous route
  • Extravasation is likely to cause tissue damage due to its low pH (ref 1)
  • Cyclizine is extremely irritant and can cause injection site reactions, including vein tracking, erythema, pain, rash, thrombophlebitis and blisters (ref 1)

Storage

Store below 25°C

References

SPC July 2018

1: Injectable Medicines administration guide, downloaded from Medusa 14/10/2021

Therapeutic classification

Drug used in nausea and vertigo

IV Guide Type