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Cefiderocol Sulfate Tosylate Intravenous Infusion for Adults
Who can administer
- May be administered by registered competent doctor or nurse/midwife
Important information
- Risk of under-dosing if displacement value not accounted for see table 1
- Restricted to Microbiology or Infectious Diseases advice only (Red-light antimicrobial)
- If documented immediate, or severe delayed hypersensitivity REACTION to PENICILLIN or CEPHALOSPORIN: DO NOT GIVE THIS DRUG
- See under 'Dose' for adjustments required in renal impairment
- Note high salt content. A 2g dose is approximately 35% of WHO adult recommended maximum daily dietary intake. Refer to SPC for further information
Available preparations
Fetcroja 1g vial
Reconstitution
- Add 10mL of sodium chloride 0.9% or glucose 5% to each 1g vial, taken from the same bag
- Shake vial gently to dissolve powder and stand vial until surface foaming disappears (usually within 2 minutes)
- Dilute further prior to administration by returning the reconstituted vials to the bag- see dosing table below for further details
Infusion fluids
Sodium Chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion (Table 1)
- Add required dose to infusion fluid (volume below) and administer over 3 hours
Cefiderocol dose | Number of 1g cefiderocol vials to be reconstituted | Volume to withdraw from reconstituted vial(s) |
Total volume of cefiderocol solution required for further dilution. Remove this volume for an infusion bag (minimum bag volume 100ml) and replace with the drug solution |
---|---|---|---|
2g | 2 vials | 11.2 mL (entire contents) from both vials | 22.4mL |
1.5g | 2 vials | 11.2 mL (entire contents) from first vial AND 5.6 mL from second vial | 16.8mL |
1g | 1 vial | 11.2 mL (entire contents) | 11.2mL |
0.75g | 1 vial | 8.4 mL | 8.4mL |
- Do not use discoloured solutions or solutions with visible particulates
Dose in adults
Usual Dose (Table 2) (ref 1)
- Give 2g every 8 hours
- An increased frequency can be used in severe infection, based on renal function (see table below). However this must be done on a case by case basis in discussion with micro/ID
- Creatinine clearance must be calculated using Cockcroft and Gault equation rather than using eGFR
.
CrCl (mL/min) | Dose | Frequency |
---|---|---|
>120ml/min | 2g | Every 6 hours |
60 to 120 | 2g | Every 8 hours |
30 to 60 | 1.5g | Every 8 hours |
15 to 30 | 1g | Every 8 hours |
<15 | 0.75g | Every 12 hours |
Storage
Store in a refrigerator 20 to 80C
References
SPC April 2020
1: Sanford guide- checked 24/11/2011
Therapeutic classification
Antimicrobial
IV Guide Type