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Avibactam/Ceftazidime Intravenous Infusion for Adults
Who can administer
May be administered by competent doctor or nurse/midwife
Important information
- Restricted to Microbiology or Infectious Diseases advice only (Red-light antimicrobial)
- If documented immediate, or severe delayed hypersensitivity REACTION to PENICILLIN or CEPHALOSPORIN: DO NOT GIVE THIS DRUG
- See under Dose for adjustments required in Renal impairment
- Dosing is based on the sum of the individual components. Zavicefta 2.5g contains ceftazidime 2g and avibactam 0.5g
Available preparations
Zavicefta 2.5g vial (ceftazidime 2g and avibactam 0.5g)
Reconstitution
Water for injection
- 10ml per 2.5g vial (gives a FINAL concentration of 2.5g in 12ml)
- Shake to give a clear solution. Once the product has dissolved, insert a gas relief needle to relieve the internal pressure
- Immediately transfer required dose to an appropriate volume infusion bag (see table below) (time from starting reconstitution to addition into infusion bag preparation must be less than 30 minutes)
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion
- Add required dose to infusion fluid (volume below) and administer over 2 hours
| Required Dose | Volume of reconstituted solution prior to addition to infusion bag | Volume of infusion bag |
|---|---|---|
| 2.5g (2g/0.5g) | 12ml (entire contents) | 100 to 250ml |
| 1.25g (1g/0.25g) | 6ml | 100ml |
| 937.5mg (750mg/187.5mg) | 4.5ml |
87ml (remove 13ml from 100ml bag) |
Note: 50ml infusion may be used if required for all doses (e.g. fluid restriction) but the residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
Dose in adults
Usual dose
- Give 2.5g (2g/0.5g) every eight hours
Renal impairment (ref 1)
- CrCl 31 to 50 ml/minute: give 1.25g (1g/0.25g) every 8 hours
- CrCl 16 to 30 ml/minute: give 937.5mg (750mg/187.5mg) every 12 hours
- CrCl 6 to 15ml/minute: give 937.5mg (750mg/187.5mg) every 24 hours
- End stage renal disease including on haemodialysis: give 937.5mg (750mg/187.5mg) every 48 hours. On haemodialysis days, administer dose following completion of dialysis
Hepatic impairment
- No dosage adjustment required
Further information
- The final concentration of the infusion must be between 8 and 40mg/ml of ceftazidime component, hence the specific volumes recommended above
Storage
- Store below 250C
- Complete preparation of the intravenous infusion within 30 minutes of starting reconstitution
References
SPC February 2021
Therapeutic classification
Cephalosporin antibiotic (third generation) with beta-lacatamase inhibitor