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Amoxicillin Intravenous for Adults
Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
- Penicillin antibiotic
- See under 'Dose' for adjustments required in renal impairment
Available preparations
Amoxicillin 500mg (Delbert)
Clamoxyl or Amoxil 500mg vial (ref 1)
Amoxicillin 1g vial (Wockhardt) (unlicensed)
Reconstitution
Water for injection
10ml per 500mg vial
20ml per 1g vial
The dilution may be carried out in a syringe as the full 10ml will not fit into the vial
Infusion fluids
Sodium chloride 0.9%
Methods of intravenous administration
Can use either method of administration- choice depends on practicalities such as time available, fluid status of patient, etc.
Slow intravenous injection (doses up to 1g) (ref 2)
- Administer over 3 to 4 minutes
Intermittent intravenous infusion: (all doses)
- Add the dose to 100mL and administer over 20 to 30 minutes
Dose in adults
Mild or moderate infections(BNF)
- Give 500mg every eight hours
Community acquired pneumonia (ref 1)
- Give 1g every eight hours
- Given in combination with other drugs
Severe infections (BNF)
- Give 1g every six hours
Listerial meningitis (BNF)
- Give 2g every four hours
- Given in combination with other drugs
Endocarditis (BNF)
- Give 2g every four hours
- Given in combination with other drugs
Renal impairment (ref 3)
| eGFR; (ml per minute/1.73m2) | Dose | |
|---|---|---|
| Greater than 10 | No adjustment necessary | |
| less than 10 |
250mg to 1g every eight hours. High dose regimens eg endocarditis and listeria meningitis: maximum 2g every eight hours |
|
| Renal replacement therapy | Consult pharmacy or specialist information sources | |
Storage
Store below 250C
References
SPC April 2018
(1) Email on file from GSK- Clamoxyl is interchangeable with Amoxil
(2) Injectable Medicines Guide - Medusa. Accessed online 25/11/2021
(3) GUH antimicrobial guidelines
(4) Amoxicillin 500mg SPC accessed 16/12/21
Therapeutic classification
Broad-spectrum penicillin