Administration restricted- see appendix 1
Doses in the literature are usually given as Isoprenaline hydrochloride.
Doses are not equivalent for isoprenaline sulphate. Take care to use the correct version, or doses would have to be adjusted.
Isoprenaline hydrochloride 1mg in 5ml (0.2mg in 1ml, 200 micrograms in 1ml) Macure
Isoprenaline hydrochloride (Isoprenalina cloridrato monico) 0.2mg in 1ml (200 micrograms in 1ml) (unlicensed)
Already in solution
Draw up using a 5 micron filter needle
Glucose 5% (preferred(ref 2)) or Sodium chloride 0.9%
Intravenous infusion (administer using an electronically controlled infusion device)
Bradycardia due to AV block
Continuous IV infusion
Dosage table for Bradycardia due to AV block - using a 4mcg per mL solution | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Dose(mcg/kg/min) | Weight 55kg | Weight 60kg | Weight 65kg | Weight 70kg | Weight 75kg | Weight 80kg | Weight 85kg | Weight 90kg | Weight 95kg | Weight 100kg |
Rate in ml/hour of a 4microgram/ml solution prepared as above | ||||||||||
0.01 | 8.3 | 9 | 9.8 | 10.5 | 11.3 | 12 | 12.8 | 13.5 | 14.3 | 15 |
0.02 | 16.5 | 18 | 19.5 | 21 | 22.5 | 24 | 25.5 | 27 | 28.5 | 30 |
0.03 | 24.8 | 27 | 29.3 | 31.5 | 33.8 | 36 | 38.3 | 40.5 | 42.8 | 45 |
0.04 | 33 | 36 | 39 | 42 | 45 | 48 | 51 | 54 | 57 | 60 |
0.05 | 41.3 | 45 | 48.8 | 52.5 | 56.3 | 60 | 63.8 | 67.5 | 71.3 | 75 |
0.1 | 82.5 | 90 | 97.5 | 105 | 112.5 | 120 | 127.5 | 135 | 142.5 | 150 |
0.15 | 123.8 | 135 | 146.3 | 157.5 | 168.8 | 180 | 191.3 | 202.5 | 213.8 | 225 |
Dosage table for Bradycardia due to AV block - using an 80mcg per mL solution | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Dose(mcg/kg/min) | Weight 55kg | Weight 60kg | Weight 65kg | Weight 70kg | Weight 75kg | Weight 80kg | Weight 85kg | Weight 90kg | Weight 95kg | Weight 100kg |
Rate in ml/hour of an 80 microgram/ml solution prepared as above | ||||||||||
0.01 | 0.41 | 0.45 | 0.49 | 0.53 | 0.56 | 0.6 | 0.64 | 0.68 | 0.71 | 0.75 |
0.03 | 1.24 | 1.35 | 1.46 | 1.58 | 1.69 | 1.8 | 1.91 | 2.02 | 2.14 | 2.25 |
0.05 | 2.06 | 2.25 | 2.44 | 2.62 | 2.81 | 3 | 3.19 | 3.38 | 3.56 | 3.75 |
0.07 | 2.89 | 3.15 | 3.41 | 3.68 | 3.94 | 4.2 | 4.46 |
4.72 |
4.99 | 5.25 |
0.09 | 3.71 | 4.05 | 4.39 | 4.72 | 5.06 | 5.4 | 5.74 | 6.08 | 6.41 | 6.75 |
0.11 | 4.54 | 4.95 | 5.36 | 5.78 | 6.19 | 6.6 | 7.01 | 7.43 | 7.84 | 8.25 |
0.13 | 5.36 | 5.85 | 6.34 | 6.83 | 7.31 | 7.8 | 8.29 | 8.78 | 9.26 | 9.75 |
0.15 | 6.19 | 6.75 | 7.31 | 7.88 | 8.44 | 9 | 9.56 | 10.13 | 10.69 | 11.25 |
Titrate to patient response.
Search synonym: Isoproterenol
SPC (Macure pharma) June 2022
1: SPC (translated) document downloaded 7th Feb 2019
2. Injectable medicines guide, downloaded from Medusa 17/02/2025
Adrenergic and dopaminergic agent. Inotrope sympathomimetic