Who can administer
Doctor only
Important information
- This monograph refers to the use of tenecteplase for STROKE indication. For use in MYOCARDIAL INFARCTION.seeseparate monograph
- Should be used under guidance of Stroke Consultant
- Tenecteplase should ONLY BE ADMINISTERED in a line containing Sodium chloride 0.9% (AVOID Glucose 5%)
- Unlicensed preparation
Available preparations
TNKase 50mg vial powder for solution
Supplied with 10ml Water for Injection vial
Reconstitution
- Remove the shield assembly from the supplied B-D 10ml syringe (shield assembly consists of the last three components on the right hand side of the picture above) - do not discard this part as it is required later
- Aseptically withdraw 10ml Water for injection from the supplied diluent vial using the syringe with the red hub cannula (must use Water for injection vial that is supplied with the product)
- Inject this 10ml diluent into the vial containing the drug, directing the diluent stream into the powder.
- Slight foaming on reconstitution is to be expected.
- Allow to stand for several minutes to allow bubbles to dissipate
- Gently swirl until the contents are completely dissolved and DO NOT SHAKE
- Withdraw the required volume into the syringe, using the red hub cannula
- Using the shield assembly device that was removed earlier: stand the shield vertically on a flat surface (with green side down) and passively recap the red hub cannula
- Remove the entire shield assembly, including the red hub cannula by twisting counter-clockwise.
Infusion fluids
Methods of intravenous administration
Bolus Intravenous Injection
- Administer over approximately 10 seconds
Dose in adults
Dose in adults:
- Give 0.25mg/kg (MAXIMUM of 25mg) as a single IV bolus over approximately 10 seconds
- See table below
- A pre-existing intravenous line may be used, ONLY if sodium chloride 0.9% has been infused (AVOID glucose 5%).
| Patient weight (kg) |
Tenecteplase dose (mg) |
Volume of reconstituted Tenecteplase solution required (mL) |
| 30 |
7.5mg |
1.5mL |
| 35 |
8.75mg |
1.75mL |
| 40 |
10mg |
2mL |
| 45 |
11.25mg |
2.25mL |
| 50 |
12.5mg |
2.5mL |
| 55 |
13.75mg |
2.75mL |
| 60 |
15mg |
3mL |
| 65 |
16.25mg |
3.25mL |
| 70 |
17.5mg |
3.5mL |
| 75 |
18.75mg |
3.75mL |
| 80 |
20mg |
4mL |
| 85 |
21.25mg |
4.25mL |
| 90 |
22.5mg |
4.5mL |
| 95 |
23.75mg |
4.75mL |
| 100 |
25mg (maximum dose) |
5mL (maximum volume) |
Monitoring
Storage
- Store unreconstituted product at room temperature
References
TNKase SPC January 2018
Therapeutic classification
Thrombolytic
