Ceftolozane/Tazobactam Intravenous Infusion for Adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Important information

  • Zerbaxa vial contains ceftolozane 1g and tazobactam 0.5g. Prescribe as combination i.e. 1g/0.5g, 2g/1g etc
  • Restricted to Microbiology or Infectious Diseases advice only (Red-light antimicrobial)
  • If documented IMMEDIATE, or SEVERE DELAYED hypersensitivity REACTION to PENICILLIN, CEPHALOSPORINS or CARBAPENEMS: DO NOT GIVE THIS DRUG
  • Contains Sodium (10mmol per vial)
  • See under Dose for adjustments required in Renal impairment

Available preparations

Zerbaxa vial (ceftolozane 1g and tazobactam 0.5g)

Reconstitution

Water for injection or Sodium chloride 0.9%

  • 10ml per 1.5g vial
  • Shake gently to dissolve the powder
  • Final volume 11.4ml per vial
  • Dilute further prior to administration

Infusion fluids

Sodium chloride 0.9% or Glucose 5%

Methods of intravenous administration

Intermittent intravenous infusion

  • Any dose may be added to 100ml infusion fluid and administer over 60 minutes
Dose of Ceftolazone/tazobactam Volume of reconstituted injection
2g/1g 22.8ml (two vials)
1.5g/0.75g 17.1ml
1g/0.5g 11.4ml (one vial)
500mg/250mg 5.7ml
300mg/150mg 3.5ml
250mg/125mg 2.9ml
100mg/50mg 1.2ml

Dose in adults

Complicated intra-abdominal infection, Complicated urinary tract infection, Acute Pyelonephritis

  • Give 1g ceftolazone / 0.5g tazobactam (one vial) every eight hours

Hospital acquired pneumonia, including ventilator-associated pneumonia

  • Give 2g ceftolazone /1g tazobactam (two vials) every eight hours
Renal impairment (ref 1)
See table in Methods of administration for how to work out doses below- eg 500mg/250mg- use 5.7ml reconstituted solution
Estimated CrCl (ml/min) Complicated intra-abdominal infection, Complicated urinary tract infection, Acute Pyelonephritis Hospital acquired pneumonia, including ventilator-associated pneumonia
30 to 50 give 500mg cetolazone / 250mg tazobactam every 8 hours give 1g ceftolazone /0.5g tazobactam every 8 hours
15 to 29 give 250mg ceftolazone / 125mg tazobactam every 8 hours give 500mg ceftolazone /250mg tazobactam every 8 hours
End stage renal disease or Haemodialysis give a single loading dose of 500mg cetolazone /250mg tazobactam, followed 8 hours later by maintenance dose of 100mg ceftolazone /50mg tazobactam every 8 hours. Administer dose immediately after dialysis on dialysis days give a single loading dose of 1.5g ceftolazone /0.75g tazobactam, followed 8 hours later by maintenance dose of 300mg ceftolazone / 150mg tazobactam every 8 hours. Administer dose immediately after dialysis on dialysis days

Hepatic impairment

  • No dosage adjustment required

Storage

  • Store between 2 and 80C

References

  • SPC 17th April 2020

1: eGFR used instead of CrCl- as approved by AST. Email on file from Dr Una NiRiain 10/01/2017

Therapeutic classification

Cephalosporin antibiotic (fifth generation) with beta-lacatamase inhibitor