Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
- Reserve antimicrobial: Restricted to indications in the antimicrobial prescribing guidelines, or following approval by microbiology/infectious diseases
Available preparations
Zedbac 500mg vial
Reconstitution
Water for injection
4.8mL per 500mg vial
The resulting concentration is 500mg in 5mL (100mg per mL)
Dilute further prior to administration
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion
- Add 500mg to 250mL infusion fluid and administer over 60 minutes
- Alternatively may add 500mg to 500mL (1mg per mL) and administer over three hours
Dose in adults
Usual dose
- Give 500mg every twenty-four hours for at least two consecutive days
- Consider converting to oral equivalent as soon as clinically appropriate
Renal or hepatic impairment
- No dosage adjustment necessary for renal impairment (GFR 10 to 80mL/min)
- Caution if using in severe renal impairment (GFR<10mL/min)
- Dose adjustment is not required for patients with mild to moderate hepatic dysfunction but it should be used with caution in patients with significant hepatic disease
Storage
References
Zedbac SPC April 2022
Therapeutic classification
Macrolide antibiotic
