Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
Global shortage of Pabrinex for 16 months from April 2024
Please follow guidelines below with regard to doses
|
Stock available |
Pharmacy (location H-01) |
Emergency Department Zone B (controlled drug press - to be signed out of Pabrinex stock register) |
- Two formulations available - one for IV one for IM use (IM preparation not routinely stocked in UCH). Please ensure the correct formulation is being used for the required route.
- Facilities for treating anaphylaxis should be available when administering this preparation
Available preparations
Pabrinex IV (2 ampoules) 2 x 5ml ampoules
Ampoule No. 1 contains |
Ampoule No. 2 contains |
Thiamine Hydrochloride Ph. Eur. 250mg
Riboflavine (as Phosphate Sodium BP) 4mg
Pyridoxine Hydrochloride Ph. Eur. 50mg
|
Ascorbic Acid Ph. Eur. 500mg
Nicotinamide Ph. Eur. 160mg
Anhydrous Glucose Ph. Eur. 1g
|
Reconstitution
Already in solution
Draw up using a 5 micron filter needle
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion (administer using an electronically controlled infusion device)
- Equal volumes of the contents of ampoules no. 1 and 2 should be added to 100mL infusion fluid
- Administer over 30 minutes
- Up to three pairs of ampoules may be added to 100mL bag
- A 50mL infusion may be used if required (eg fluid restriction) but the residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
Dose in adults
Alcohol withdrawal (ref 1)
- Severe symptoms
- Do not use IV Pabrinex
- Give oral thiamine 100mg every eight hours for six weeks or until adequate nutritional status UNLESS Wernicke's encephalopathy suspected (see Wernicke's Encephalopathy below)
- Moderate symptoms
- Do not use IV Pabrinex
- Give oral thiamine 100mg every eight hours for six weeks, or until adequate nutritional status
Treatment of suspected or established Wernicke's encephalopathy (ref 1,2)
- Give two pairs every eight hours for two days, followed by one pair once daily for a further three days (followed by maintenance oral thiamine)
Storage
References
SPC November 2018
1: Local recommendations, based on expert opinion, considering worldwide shortage of Pabrinex
2: UpToDate, accessed online 29th April 2024
Therapeutic classification
Multivitamin preparations