Who can administer
Administration RESTRICTED - see Appendix 1
Important information
- Usually given by intramuscular or oral route in GUH, rather than by IV route
Available preparations
Tradol 100mg per 2ml ampoule
Reconstitution
Already in solution
Draw up using a 5 micron filter needle
Infusion fluids
Sodium Chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent Intravenous infusion (preferred over Slow IV injection)
- Add required dose to 100ml of infusion fluid and administer over 15 to 30 minutes (ref 1)
- A 50ml infusion may be used if required (e.g. fluid restriction) but the residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
Slow Intravenous Injection
- Administer over 2 to 3 minutes
- Rapid intravenous injection may be associated with a higher incidence of adverse events and therefore should be avoided.
Dose in adults
Usual dose for moderate to severe pain
- Give 50 to 100mg every 4 to 6 hours
- Usual maximum: 400mg daily
- Elderly patients (>75years): May need to extend dosage interval
- Post-operative pain: Different dosage regimes have been used (higher doses for first hour) - see SPC
Renal impairment
Hepatic impairment
- Use with caution
- Consider increasing dosage interval
Monitoring
- If used in combination with SSRIs or other serotonergic agents, monitor for symptoms of serotonin syndrome (e.g. agitation, tremor, fever or diarrheoa)
Storage
References
Tradol SPC October 2021
1:Medusa Injectable Medicines Guide downloaded 13/04/2022
Therapeutic classification
Opioid analgesic
