Parecoxib intravenous for adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Available preparations

Dynastat 40mg vial

Reconstitution

Sodium chloride 0.9% or Glucose 5% - add 2ml per 40mg vial

Dissolve the powder using a gentle swirling motion

Methods of intravenous administration

Bolus intravenous injection

• Administer slowly over at least 3 minutes ^{(ref 1)}

Dose in adults

Usual dose

• Give 40mg stat., followed by 20 to 40mg every six to twelve hours as required
• Maximum dose 80mg daily
• Use for the shortest duration possible, at the lowest effective dose
• There is limited clinical experience with treatment beyond three days

Elderly patients (65 years or more) weighing less than 50kg

• Use half initial dose, maximum daily dose 40mg

Renal impairment

• Severe renal impairment (CrCl <30ml/minute), or patients predisposed to fluid retention: Start with 20mg and monitor renal function closely

Hepatic impairment

• Severe impairment (Child Pugh 10 or more) Contraindicated
• Moderate impairment (Child Pugh 7 to 9): Use half the recommended dose (maximum daily dose 40mg)
• Mild impairment (Child Pugh 5 - 6): No dosage adjustment necessary

Storage

Store at room temperature

References

SPC May 2024

1: Medusa- downloaded May 12th 2026

Therapeutic classification

Anti-inflammatory agent (selective COX-2 inhibitor)