Ibuprofen Intravenous Infusion for Adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Important information

• Ibuprofen (IV route) is indicated for short term use when other routes of administration are not possible - usual maximum three days
• Check whether NSAIDs are also being given by other routes - to avoid inadvertant duplication of therapy
• Consider switch to oral treatment as soon as possible
• Ensure adequate hydration to minimise risk of renal adverse reactions

Available preparations

Ibuprofen 400mg in 100ml (B Braun)

Reconstitution

Already in solution

Infusion fluids

Not required - product ready for infusion

Methods of intravenous administration

Intermittent intravenous infusion

• Administer over 30 minutes

Dose in adults

Dose

• Give 400mg every 6 to 8 hours (maximum licensed daily dose is 1200mg)

Renal impairment

• Mild/moderate impairment: reduce initial dose and use at lowest dose and for the shortest duration possible
• Severe impairment: contraindicated

Hepatic impairment

• Mild/moderate impairment: reduce initial dose and use at lowest dose and for the shortest duration possible
• Severe impairment: contraindicated

Monitoring

• Monitor for signs of gastrointestinal bleeding, ulceration or perforation
• Monitor for signs of bronchospasm, urticaria or angioedema
• Monitor for oedema, hypertension and cardiac failure

Storage

Store below 25⁰C

References

SPC (B Braun) April 2024

Therapeutic classification

Non-steroid anti-inflammatory drug (NSAID)